11/5/2022 0 Comments Informationon alex p. montes![]() After extensive testing, he found a drug with activity against the bacterium Treponema pallidum, which causes syphilis. The unusual serendipity involved in the discovery of penicillin demonstrates the difficulties in finding new antibiotics and should remind health professionals to expertly manage these extraordinary medicines.ĭawn of Chemotherapy and the “Magic Bullet”Īt the beginning of the 20th century, Paul Ehrlich pioneered the search for a chemical that would kill a microorganism and leave the host unaltered-the “magic bullet.” Ehrlich also coined the term chemotherapy: “There must be planned chemical synthesis: proceeding from a chemical substance with recognizable activity, making derivatives from it, and then trying each to discover the degree of its activity and effectiveness. Researchers in the Netherlands produced penicillin using their own production methods and marketed it in 1946, which eventually increased the penicillin supply and decreased the price. Information about these efforts, available only in the last 10–15 years, provides new insights into the story of the first antibiotic. This success overshadowed efforts to produce penicillin during World War II in Europe, particularly in the Netherlands. Unprecedented United States/Great Britain cooperation to produce penicillin was incredibly successful by 1943. ![]() However, the purification and first clinical use of penicillin would take more than a decade. In 1928, a chance event in Alexander Fleming’s London laboratory changed the course of medicine. After just over 75 years of penicillin’s clinical use, the world can see that its impact was immediate and profound. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |